Diabetes

Colorectal cancer is the second most common cause of cancer-related death in the United States.

The incidence of EO-CRC, which refers to when people under 50 years of age develop the condition, has increased markedly in several wealthy countries.

One 2020 article in CA: A Cancer Journal for Clinicians suggested that over the course of the year, about 150,000 U.S. individuals would receive a diagnosis of colorectal cancer and about 53,200 would die as a result.

The authors also predicted about 18,000 cases of individuals younger than 50 years of age receiving a diagnosis of colorectal cancer, with 3,640 forecasted deaths in this population.

Compared with adults born in the U.S. around 1950, those born around 1990 have twice the risk of developing colon cancer and four times the risk of developing rectal cancer.

A new study in the journal Gut links drinking two or more SSBs per day in adulthood with a doubling in the risk of bowel cancer before the age of 50 years.

Researchers found that each daily SSB serving among adult women may be associated with a 16% higher risk of developing EO-CRC.

Also, the study found that each additional SSB serving per day among individuals aged 13–18 years may be linked to a 32% increase in the risk of developing EO-CRC.

Examples of SSBs include soft drinks, pre-packaged fruit drinks, energy drinks, and sports drinks. Sugary drinks are the leading source of added sugars in the American diet.

In fact, from 1977 to 2001, energy intake from SSBs increased by a whopping 135%.

Unique epidemiologic evidence

For this study, the researchers used data from 95,464 participants in the Nurses’ Health Study II. This is an ongoing monitoring study of 116,430 U.S. registered nurses, all women, who were aged 25–42 years when they enrolled in 1989.

Every 4 years beginning in 1991, the women in the study reported on what they ate and drank using validated food frequency questionnaires.

In 1998, researchers asked the participants to recall their health status and lifestyle habits as teenagers.

Also, 41,272 of the women reported on what they typically ate and drank as well as on the quantities of these items between 1960 and 1982. They were aged 13–18 years at this point.

The participants also gave information on potentially influential factors, including their family history of bowel cancer, their lifestyle habits, and any regular use of aspirin, nonsteroidal anti-inflammatory drugs, or vitamin supplements.

Over 24 years of monitoring, 109 women developed bowel cancer before the age of 50 years.

The study authors write that their findings “add unique epidemiologic evidence that SSB intake may partly contribute to the rapid increase of CRC in younger adults.”

Notes on the study

It is important for researchers to understand what is behind this increase, said study co-author Dr. Jeffrey Meyerhardt. He is the clinical director of the Gastrointestinal Cancer Center at the Dana-Farber Cancer Institute in Boston, MA.

“It is presumed that exposures early in life are contributing to this rise,” Dr. Meyerhardt told Medical News Today. “Studying exposures that can be prevented is [essential] to getting control of this rising health issue.”

Substituting SSBs with reduced-fat milk or whole milk appears to be beneficial, according to study co-author Dr. Yin Cao. She is an associate professor of surgery at the Washington University School of Medicine in St. Louis, MO.

“In this study,” she told us, “we showed [that] replacing one daily serving (8 oz) of SSBs with an equivalent amount of reduced-fat milk or total milk was associated with a 35–36% lower risk of EO-CRC.”

“During the second half of the 20th century, for which average U.S. per capita soft drink consumption has dramatically increased by ~500%, milk consumption has declined by half. Milk is a good source of calcium, a mineral found to be protective of colorectal cancer.”

“We postulate [that] low milk consumption could be plausibly linked with the increased risk of EO-CRC, and further research on this topic is in the pipeline.”

The researchers point to several limitations of their study. First, they caution that this was an observational study, which can only establish correlation, not cause. They also note that the majority of the participants were white women, so the findings may not apply to men or other ethnic groups.

Even so, the study provides insight into possible actions that public health leaders might take, Dr. Cao explained.

“Particularly in adolescence,” she wrote, “the immature and rapidly growing organs could be more susceptible to exposures that could lead to cancer development.”

“Campaigns, education programs, and interventions targeting the young population to reduce SSB intake and/or replace SSBs with other healthier beverages could help reduce the accrual of time at risk and convert this window of increased susceptibility into an opportunity for better health outcomes later in life.”

People who wish to look after their heart health are aware that regularly eating vegetables is key.

A new study from Edith Cowan University (ECU) in Joondalup, WA, in Australia finds that leafy greens and other vegetables high in nitrates in particular confer significant cardiovascular benefits.

Researchers found that daily consumption of a cup of vegetables rich in nitrates is associated with better heart health.

“Our results have shown that, by simply eating 1 cup of raw (or half a cup of cooked) nitrate-rich vegetables each day, people may be able to significantly reduce their risk of cardiovascular disease.”

– lead author Dr. Catherine Bondonno from ECU’s Institute for Nutrition Research

Green leafy vegetables high in nitrates include spinach, lettuce, arugula (also known as rocket), Chinese cabbage, and parsley. Non-leafy vegetables with strong nitrate content include radishes, fennel, and beet.

The researchers estimate that cooking reduces a vegetable’s nitrate content by about 50%, but that is still enough to promote heart health.

Dr. Bondonno said, “The greatest reduction in risk was for peripheral artery disease — 26% — a type of heart disease characterized by the narrowing of blood vessels of the legs. However,” she added, “we also found people had a lower risk of heart attacks, strokes, and heart failure.”

The authors note that their findings are consistent with four earlier studies.

Worldwide, roughly 17.9 million people die of heart disease each year. In the United States, it is the leading cause of death for “men, women, and people of most racial and ethnic groups,” according to the Centers for Disease Control and Prevention (CDC).

About 655,000 people in the U.S. die of heart disease every year — one out of every four deaths in the country.

The study appears in the European Journal of Epidemiology.

A long-term study

The researchers analyzed 23 years of data for 56,468 residents of Denmark who participated in the Danish Diet, Cancer, and Health Study. All individuals filled out a food frequency questionnaire, and the resulting data was cross-referenced against public health records.

Analysis revealed that people in the highest fifth of intake of vegetable nitrates exhibited a 2.58 mm Hg, or millimeters of mercury, lower systolic blood pressure — which is the first value in a blood pressure reading — compared with those in the lowest intake group (after adjustments for possible confounding differences between the groups).

The higher the nitrate intake, the greater the fall in blood pressure. The top intake group ate an average of 141 milligrams (mg) of nitrate per day. This is equivalent to 2–2.5 cups of leafy vegetables daily.

In contrast, the impact of nitrate intake on hospitalizations across all types of cardiovascular disease (CVD) plateaued at 59 mg per day. It did not increase with further nitrate intake.

Overall, there was a 15% reduction in CVD admissions over the 23 years of follow-up, compared with those with the lowest nitrate intake, which was 23 gm per day. The greatest reduction in risk — at 26% — was seen in hospitalizations for peripheral artery disease.

Speaking to Medical News TodayDr. Edo Paz of K Health, who was not involved in the research, said he considers the study significant due to its large sample size and lengthy follow-up period.

“However,” he noted, “this is an observational study, and there are some key limitations as a result.” He explained:

“In particular, it is highly likely that people who eat vegetables have other healthy behaviors that are different than those people who do not eat vegetables. For instance, these participants may be more likely to maintain a healthy weight, exercise more, smoke less, etc. Even though the authors try to account for these variables, this is still a key limitation inherent to observational studies in general.” – Dr. Edo Paz

Just a cup

The study suggests that the equivalent of a cup of raw or half a cup of cooked green leafy vegetables of this kind a day is just about the right amount for long-term heart health. “We did not see further benefits in people who ate higher levels of nitrate-rich vegetables,” said Dr. Bondonno.

“People don’t need to be taking supplements to boost their nitrate levels,” Dr. Bondonno said, “because the study showed that one cup of leafy green vegetables each day is enough to reap the benefits for heart disease.

Dr. Paz told MNT: “It’s important to remember that everything should be eaten or consumed in moderation. If extreme amounts of nitrate are ingested, it could lead to methemoglobinemia, which is a condition in which red blood cells have reduced ability to carry oxygen.”

“Fortunately, methemoglobinemia is relatively rare and is more commonly caused by nitrate contamination of drinking water.”

Dr. Bondonno does not recommend juicing vegetables if you want to enjoy the optimal nitrate benefit, since juicing removes pulp and fiber.

On the other hand, blending vegetables is fine. She recommends including a cup of spinach in a berry smoothie as an easy, enjoyable way for people to consume their vegetables.

If you are looking for the best natural skin care treatment, Moringa Oleifera, the plant native to India and now grown in more than 80 countries is your best option. Moringa oil is extracted from the nuts of the Moringa plant to make the most trustworthy natural skincare products.

We Asked Mr Amrit Walia, Co-Founder of Pioneer Sustainable Agriculture here in Nigeria who also produces one of the best premium cold-pressed oil ( Puro moringa oil ) coming straight from organic moringa farms, to know more about Moringa oil and why it is highly coveted in the cosmetic and lubricating industry, and this is what we got, enjoy reading.

In cosmetics, Moringa oil is a primary ingredient in the manufacture of expensive, natural fragrances and perfumes. The oil is also included in skin scrubs, soaps, and shampoos, lip balm, lotions and is the foremost ingredient in the manufacture of blended massage oil.

As an agent to beauty, Moringa oil is used for a manicure, pedicure, and in making beauty soap which utilizes its skin cleansing and moisturizing properties. Moringa oil can sometimes be used to dress vegetables, salads, and various green dishes. In cooking, the amazing oil can be used for deep frying and sautéing.

1. Moringa Oil as a Skin Care Agent
This oil is rich in fatty acids like Oleic acid which automatically restores the skin’s natural barrier and in keeping the skin hydrated.
Moringa has antibacterial, antioxidant, and antifungal properties that can do the following concerning skincare:

  • The unique combination of fatty acids in the oil is essential for maintaining cell membranes. The fatty acids also possess lubricant, and anti-inflammatory properties that restore the lost natural oils and protect the skin from damage in a hostile environment.
  • Moringa’s phytochemical profile can defend the skin from ongoing pollution which adversely affects the epidermis of the skin. The rich content of Oleic acid also keeps the skin hydrated despite exposure to pollution.
  • Moringa works as an anti-aging oil. By fighting the activity of free radicals, it slows down the process of aging, prevents sagging of facial skin, and clears wrinkles.
  • Moringa oil regulates oil secretion and purifies the skin from the harmful effects of pollution thus revealing the natural glow.
  • It is a super antiseptic containing antimicrobial properties capable of curing acne and dark spots. It also regulates the production of excess sebum and removes dirt and bacteria clogged on the pores of the skin.
  • Moringa oil is an amazing deep skin cleanser and skin detoxifier. It contains sulfur which helps in building natural keratin for youthful skin.

2. Moringa Oil in Health Care
Moringa tree oil has 90 different types of nutrients, 46 antioxidant proteins, and 36 anti-inflammatory agents.

This comes along with many health benefits including, but is not limited to the following:

  • Soothing the nervous system
  • Protecting bones
  • Optimal gum and oral health
  • Management of hysteria
  • Fights stomach disorders
  • Fights asthma
  • Fights arthritic pain
  • Softens and heals cracked heels
  • Heals insomnia
  • Treats sunburns
  • Provides stronger hair
  • Acts as a rheumatic oil
  • Cures hypertension

Conclusion
There are still more uses of Moringa oil, which truly reveals how beneficial this oil is to your overall health.

Moringa oil can also be applied effectively in the management of hysteria, fighting asthma, management of arthritic pain, treatment of stomach disorders, softening and healing cracked heels, in the treatment of sunburns, and in the treatment of hypertension, insomnia, and many other conditions.

You can try this natural extract and start enjoying most of its health benefits today.

Eating fruit is a delicious way to satisfy hunger and meet daily nutritional needs. However, most fruits contain sugar. This has raised questions about whether fruits are suitable for people who have diabetes.

Diabetes is a chronic but manageable condition in which the body struggles to control the levels of blood sugar.

Is fruit dangerous for people with diabetes? This article will suggest fruits to eat and avoid if you have diabetes, as well as examining the relationship between fruit and blood sugar.

List of fruits for diabetes

fruits for diabetes on heart shaped platter
People with diabetes can eat fruit.

Below is a list of fruits divided by GI index, as reported by the U.S. Department of Agriculture (USDA).

Low GI and GL fruits

Some fruits have a GI of under 55 and a GL under 10, including.

  • apples
  • avocados
  • bananas
  • berries
  • cherries
  • grapefruit
  • grapes
  • kiwi fruit
  • nectarines
  • orange
  • peaches
  • pears
  • plums
  • strawberries

Medium-GI fruits (GI of 56 to 69)

A fruit with a GI of between 56 and 69 is considered to be a medium-GI food. All fruits listed below still have GL levels under 10.

  • honeydew melon
  • figs
  • papayas
  • pineapples

High-GI fruits

Fruits with a GI higher than 70 are high-GI and a GL of greater than 20 is high GL. While these are safe to eat with diabetes, it is important to eat larger quantities of lower-GI fruits instead.

  • dates (high GL)
  • watermelon (low GL)

Fruit and diabetes

The American Diabetes Association (ADA) advises that any fruit is fine to eat for a person with diabetes, so long as that person is not allergic to a particular fruit.

meta-analysis published in 2014 in the British Medical Journal found higher fruit intake was significantly associated with a lower risk of type 2 diabetes.

The preparation of fruit, however, can affect blood sugar. Fresh or frozen fruits are better than processed fruits straight from a can or jar, such as applesauce and canned fruit. Processed fruits also include dried fruit and fruit juices.

People with diabetes should eat processed foods sparingly or avoid them completely. The body absorbs processed fruits more rapidly, leading to higher blood sugar levels. Processing fruits also removes or reduces levels of certain key nutrients, including vitamins and fiber.

The National Institute of Diabetic and Digestive and Kidney Diseases (NIDDK) recommends that people with diabetes should avoid fruit juices or canned fruits with added sugar.

Fruit blends like smoothies also have high sugar content and are more rapidly absorbed leading to higher spikes in blood sugar.

What is the glycemic index?

For a person with diabetes, one way to select safe and suitable fruits and other high-carbohydrate foods is to check the glycemic index (GI).

GI is a rating of foods on a scale from 1 to 100. The score indicates how quickly the food item may raise blood sugar levels.

High GI foods are absorbed faster than medium or low GI foods.

Glycemic load (GL) takes into account the GI of a food plus the number of carbohydrates in a serving. GL may be a more accurate way of assessing how food affects blood sugar management over time. Low-GI and low-GL foods are better for helping control blood sugar levels.

People may be surprised to learn that many fruits have a low glycemic index. People digest starchy vegetables, such as potatoes and grains, more rapidly, so these have a higher GI index.

The longer a carbohydrate-rich food is cooked, the higher the GI value. Fat, fiber content, and cooling carbohydrates after they have been transformed into resistant starches via cooking can all dramatically lower GI values.

Benefits for diabetes

lemon eyes
Fruit plays a key role in helping people with diabetes feel full and absorb sugar slowly.

Eating enough fiber plays an important role in managing diabetes.

A diet high in soluble fiber can slow the absorption of sugar and control its levels in the blood. Many fruits are high in fiber, especially those with the skin or pulp included.

Many fruits are filling because of their high fiber and water content.

Diets containing enough fruits and vegetables can reduce the risk of obesityheart attack, and stroke. Obesity has been linked to type 2 diabetes.

Fruits are high in fiber and nutrients, so they are a good choice in meal planning. Fruits that have been processed such as applesauce and fruit juices have had their fiber removed and should be limited.

Other health benefits of fruit

The good news is that fruit is healthy to eat for people with diabetes, according to the NIDDK.

People with diabetes should eat a balanced diet that provides enough energy and helps to maintain a healthy weight. Some fruits are high in sugar, such as mangoes, but can be part of a healthy diet in moderate amounts.

Fruits can also satisfy a sweet tooth without resorting to candy and other foods with low nutritional value. Most fruits are high in nutrients and low in fat and sodium. Fruits also often contain nutrients not found in other foods.

Bananas contain potassium and tryptophan, an important amino acid. Citrus fruits like oranges and grapefruits are high in vitamins A and C, which are powerful antioxidants.

How much fruit should I eat?

Most guidelines recommend that adults and children eat five servings of fruits and vegetables each day. This does not change for people with diabetes.

The United States guidelines recommend that people fill half of their plate at each meal with fruits and vegetables.

People with diabetes should focus on non-starchy vegetables for 50 percent of the meal, rather than depending on fruit. The remaining half of the meal should be protein and high-fiber starches like beans or whole grains. Many experts also recommend including healthy fat at each meal to encourage feeling full and enhance absorption of antioxidants and vitamins.

One serving is a medium-sized fruit, or a serving the size of a baseball. Smaller fruits, such as berries, have one-cup as the serving size.

A half-cup is also the serving size for processed fruit products, such as applesauce and fruit juice. The serving for fried fruits like raisins and cherries is 2 tablespoons per serving size.

Like vegetables, it’s great for people to eat a variety of fruits to get their needed nutrients, as well as to enjoy their varied flavors.

Dietary tips

To achieve the desired five servings of fruits and vegetables per day, people should aim to have fruit or vegetables throughout the day.

Here are a few ideas to help with menu planning:

Citrus fruits

Citrus fruits are versatile and easy to add to meals. Add lemons and limes to seafood, sauces, or glasses of iced tea or water.

People can make their own fruit water by adding citrus slices to a pitcher of water. Let the water sit overnight to create a refreshing drink.

Berries

Berries are tasty when eaten raw and can also be cooked into a compote to spoon into oatmeal or meat.

Put whole fresh or frozen berries into a saucepan with a tablespoon or two of water. Cook on medium or low heat until the berries have broken down into a thick sauce.

One serving is half a cup.

Apples

Apples are a popular fruit. They are delicious raw for a snack or dessert. When cooked, apples have a deeper flavor, making them a favorite in cooked desserts when spiced with cinnamon or ginger.

recipe from the ADA suggests marinating apples in a small amount of honey and spices and then cooking them on a grill. To finish, roll the apples in crushed walnuts or pecans.

While still containing honey, this is a healthier alternative to many apple-based baked goods.

Avocados

Avocados are high in fat, but they contain monounsaturated fat, the type of fat that is beneficial for the body.

They are eaten raw and can be served sliced, in salsas, or as guacamole. Avocados are easy to prepare by slicing them in half around the pit. Discard the pit and mash the avocado.

Add herbs and vegetables to taste. Lime or lemon can also be added to avocado for a citrus boost.

People may have been producing and drinking kefir, a fermented milk drink that originated in Tibet and the North Caucasus, for thousands of years.

People can make the sour, slightly effervescent brew by infusing milk with kefir grains, which are a starchy matrix containing a symbiotic community of lactic acid bacteria, acetic bacteria, and yeasts.

The drink has many reputed health benefits, which include lowering cholesterol, reducing inflammation, and exerting an antioxidant effect.

In common with other probiotics, kefir also has antimicrobial properties. However, scientists were unsure exactly how it inhibits the growth of disease-causing bacteria.

Researchers at Ben-Gurion University of the Negev (BGU) in Be’er Sheva, Israel, have now discovered that a type of yeast in kefir called Kluyveromyces marxianus secretes a molecule that disrupts bacterial communication.

Scientists already knew that plants and algae produce this substance, called tryptophol acetate, but this is the first time that they have found a yeast that makes it.

They discovered that tryptophol acetate interferes with “quorum sensing” — a form of microbial communication — in several disease-causing bacteria.

In quorum sensing, bacteria release signaling molecules into their surroundings. When the molecules reach a particular concentration, they trigger changes in the expression of genes in bacteria of the same species.

These changes allow disease-causing bacteria to coordinate their activity according to their numbers. This coordination is necessary for some bacteria to defend themselves or attack their hosts.

In some cases, when they reach a certain density, the microbes may come together to form a slimy, protective coating, or “biofilm,” on a surface.

Disease-causing bacteria

In lab cultures, the researchers found that tryptophol acetate had an inhibitory effect over quorum sensing in several disease-causing bacteria, including some Gram-negative bacteria.

Some of the tested species were:

  • Pseudomonas aeruginosa, which causes pneumonia when it infects the lungs.
  • S. enterica, which is responsible for food poisoning.
  • Staphylococcus aureus, which can trigger sepsis, among other life threatening infections.
  • V. cholerae, which causes cholera.

The research, which Ph.D. student Orit Malka led, appears in the journal BMC Microbiome.

“These results are notable, since this is the first demonstration that virulence of human pathogenic bacteria can be mitigated by molecules secreted in probiotic milk products, such as yogurt or kefir,” says senior author Prof. Raz Jelinek.

The scientists focused in particular on the effect of tryptophol acetate on V. cholerae.

They found that the substance blocked quorum sensing in this bacteria and reduced its virulence.

It did this by changing the expression of bacterial genes that control quorum sensing.

The researchers write that this kind of interference in bacterial communication may be commonplace in complex environments where many different microorganisms live together, such as in probiotic food or the human gut.

Antibiotic resistance

The development of antibiotic resistance in bacteria poses a major threat to public health.

In recent years, scientists have begun to explore alternatives to conventional antibiotics, including drugs that interfere with quorum sensing.

The researchers behind the latest discovery have set up a company to develop and market tryptophol acetate and other small molecules through BGN Technologies, which is BGU’s technology transfer organization.

“In a world where antibiotic resistant bacteria are becoming an imminent threat, the novel molecules discovered by BGU scientists pave a completely new path for fighting bacterial infections by disrupting cell-cell communications in pathogenic bacteria.”– Josh Peleg, CEO of BGN Technologies.

In a follow-up study, which they have not yet published, the researchers discovered that the same molecules might have anti-inflammatory properties.

According to the scientists, their work in animal models of disease hints that the molecules could calm the excessive immune response known as the cytokine storm that has occurred in some people with severe COVID-19.

The miracle tree, Moringa, Moringa Oleifera, or the drumstick is a plant recognized for its medical properties. It is used to treat more than 300 conditions. All parts of the Moringa tree possess some medicinal or nutritional value” says Amrit Walia ( Amritpal Singh Walia ) Co-Founder of Pioneer Sustainable Agriculture PSA organic farm located in Nigeria.

One cup of fresh, chopped leaves contains protein, Vitamin B6, Vitamin C, Iron, Magnesium, Riboflavin, and Vitamin A.

In this article, you will be able to understand the five prime uses of Moringa leaf that clearly distinguished it as an extraordinary species:

1. Moringa Leaf is Rich in Antioxidants
Moringa acts to reduce high levels of free radicals which may cause oxidative stress leading to diseases like type 2 diabetes or heart disease.

The basic antioxidants in Moringa are beta-carotene and Vitamin C. The exact figure of the number of antioxidants in the Moringa herb is staggering.

A few antioxidants present include propyl gallate, tocopherols (Vitamin E), ascorbic acid, chlorogenic acid, hydroxyanisole (BHT) citric acid, vanillin, potassium, reduced glutathione, and more. Quercetin is also present and crucial in the regulation of blood pressure.

2. Moringa Leaf Regulates Blood Sugar
Moringa herb produces effects similar to isothiocyanates plant compounds able to regulate blood sugar.
Sufficient research shows a significant reduction in blood sugar after short-term use of the herb with meals.

For instance, it was discovered that a group of diabetics who added 50 grams of moringa leaves to a meal reduced the rise in blood sugar by 21%.

3. Moringa Leaf Works to Reduce Inflammation
If you incur injury and develop wounds, Moringa can help you to stop inflammation.

Moringa is stocked with nutrients and antioxidants which are found in other anti-inflammatory foods like tomatoes, fatty fish, olive oil, and certain fruits.

By fighting harmful free radicals, the herb prevents sustained inflammation which can result in chronic problems like cancer or heart disease.

4. Moringa Leaf Promotes Prostate Health and Cure ED
The leaves and seeds of the Moringa plant are rich sulfur-containing compounds called glucosinolates, which fight cancer in the body, more specifically, benign prostate hyperplasias.

The condition which is prone to attack elderly man is characterized by enlargement of the prostate which makes urination difficult. Moringa can reverse the effects of prostate cancer by significantly reducing prostate weight.

The herb also reduces levels of prostate-specific antigen which is produced by the prostate gland.

Moringa can also cure erectile dysfunction. Its leaves contain useful plant compounds called polyphenols which enhance blood flow by increasing nitric oxide production while simultaneously lowering blood pressure.

Conclusion
The points discussed above show how versatile Moringa leaf is in the fields of health and medical care. The plant can be used for detoxification and in the treatment of digestive disorders.

The list of other ailments this wonder plant can treat include the following – scurvy, kidney stones, Athlete’s foot, dandruff, epilepsy, paralysis, convulsions, splenomegaly, epilepsy, antispasmodic, joint pain, edema, rheumatism, arthritis, cardiac hypertrophy, coronary artery disease, myocardial infarction, heart failure, and many more.

Do you have any experience with the Moringa Leaf extracts? Kindly share with us in the comments below.

Scientists have offered a detailed view of the biochemical pathway surrounding Parkin — a protein that plays a key role in maintaining cellular energy.

The research, which appears in the journal Science Advances, may help scientists develop new treatments for Parkinson’s disease, type 2 diabetes, and cancer, which can all occur when Parkin is not functioning properly.

Mitophagy

Parkin’s central role is to remove damaged mitochondria, which are the power stations of the cell that are responsible for generating energy. Cellular stress can damage mitochondria.

Damaged or dysfunctional mitochondria tend to accumulate in the cell, and the body needs to clear them away using a process known as mitophagy. This process is essential for cell health and energy production.

Researchers have implicated mitochondrial dysfunction in neurodegenerative diseases such as Parkinson’s.

A key question for scientists has been how Parkin is able to respond to cellular stress so quickly. The signal for Parkin to do its work appeared to occur after it had already started.

Biochemical pathways

In the present study, the scientists gained a better perspective on the biochemical pathway that signals Parkin to clear away damaged mitochondria.

According to Prof. Reuben Shaw, director of the Salk Cancer Center in La Jolla, CA, and senior author of the study, “our findings represent the earliest step in Parkin’s alarm response that anyone has ever found by a long shot.”

“All the other known biochemical events happen at 1 hour; we have now found something that happens within 5 minutes.”

“Decoding this major step in the way cells dispose of defective mitochondria has implications for a number of diseases.”

Building on their prior research, the scientists searched for proteins that activate in response to the enzyme ULK1, which the enzyme AMPK triggers. They found that Parkin was a prime candidate.

The results were surprising as biochemical pathways are normally very complicated, involving up to 50 different proteins.

The scientists confirmed the findings using mass spectrometry. This process revealed how ULK1 was interacting with Parkin, offering a detailed view of how the various proteins work together.

It is this chain, from AMPK to ULK1 to Parkin, that accounts for the speed with which Parkin can react to cellular stress.

Future treatments?

By drawing a link between Parkin and AMPK, the research may aid in the development of new treatments for various diseases.

For Prof. Shaw, “the big takeaway […] is that metabolism and changes in the health of your mitochondria are critical in cancer, they are critical in diabetes, and they are critical in neurodegenerative diseases.”

“Our finding says that a diabetes drug that activates AMPK, which we previously showed can suppress cancer, may also help restore function in patients with neurodegenerative disease.”

“That is because the general mechanisms that underpin the health of the cells in our bodies are way more integrated than anyone could have ever imagined.”

Stressful events — such as sitting an exam, giving a presentation, or attending a job interview — temporarily increase heart rate and blood pressure and dilate arteries.

This is a normal part of the body’s “fight-or-flight” response, but the lining of blood vessels, known as the endothelium, can take up to 90 minutes to recover after this kind of stress.

This may help to explain why a single episode of stress temporarily increases the risk of an acute cardiovascular event, such as a heart attack.

On the other hand, experts know that eating a diet rich in fruits and vegetables reduces a person’s risk of cardiovascular disease, heart attacks, and cardiovascular mortality.

Among the healthy nutrients found in fruits and vegetables are polyphenolic compounds known as flavanols. In the long term, these improve endothelial function and lower blood pressure.

The effects of flavanols during stress and in its immediate aftermath are unknown, however.

Scientists at the University of Birmingham in the United Kingdom have conducted the first study to investigate this question.

Their research suggests that drinking cocoa, which is rich in flavanols, in the hours before a stressful event can improve blood flow during the experience and help restore endothelial function in males aged under 45 years old afterward.

“Our findings are significant for everyday diet, given that the daily dosage administered could be achieved by consuming a variety of foods rich in flavanols — particularly apples, black grapes, blackberries, cherries, raspberries, pears, pulses, green tea, and unprocessed cocoa,” says senior author Dr. Catarina Rendeiro, Ph.D., of the university’s School of Sport, Exercise and Rehabilitation Sciences.

“This has important implications for measures to protect the blood vessels of those individuals who are more vulnerable to the effects of mental stress,” she adds.

The research, conducted by postgraduate student Rosalind Baynham, appears in the journal Nutrients.

Stress tests

The scientists recruited 30 healthy males between 18 and 45 years who underwent tests at the lab on two separate occasions at least 7 days apart.

The research involved them fasting for 12 hours before each session and abstaining from alcohol, vigorous exercise, and polyphenol-rich food and drink for 24 hours beforehand.

At the start of each visit, while the participants were relaxed, researchers assessed their “brachial flow-mediated dilatation,” which is a measure of endothelial function.

They also measured their blood pressure, heart rate, and blood flow.

On one of these visits, the participants drank regular cocoa, which is rich in flavanols, and on the other visit, they drank a special cocoa drink that was low in flavanols.

About 90 minutes later, they took a competitive test of mental arithmetic designed to elicit stress.

For example, during the test, the researchers filmed the participants, and they had to watch their performance on a screen. The researchers told the participants that “body language assessors” would assess them.

The arithmetic task got progressively faster, and the participants lost points whenever they got an answer wrong.

An experimenter in the room marked their responses and sounded an alarm when they made a mistake, or once every 10 answers if they did not.

At 30 and 90 minutes after the stress test, the researchers remeasured the participants’ endothelial function and blood pressure.

The results showed that 30 minutes after the stress test, all participants had impaired endothelial function. This measure remained significantly higher 90 minutes after the stress test.

However, participants who drank the high-flavanol cocoa saw smaller declines in endothelial function than those who consumed the low-flavanol cocoa.

In addition, high-flavanol cocoa increased blood flow during and after the test compared with low-flavanol cocoa.

Other cardiovascular and blood pressure measures were similar for both conditions.

Future investigations

The researchers note that the main limitation of their study was that it excluded females.

They report that, for the sake of consistency, they wanted to avoid the impact of hormonal fluctuations during the female menstrual cycle on the vascular changes under investigation.

This means that it is not possible to apply the outcomes of this study to females. Researchers remain unclear on the impact of flavanols on stress response in females.

However, existing evidence shows there are gender differences in how a body responds to stress. So, future studies should focus on females.

The researchers also write that a more in-depth investigation would include molecular measures of cardiovascular function. These should consist of nitric oxide, which is a signaling molecule that dilates blood vessels, and the stress hormone cortisol.

Finally, they write that future research should explore the effect of flavanol intake on stress responses in individuals at higher risk of cardiovascular diseases, such as high blood pressure, and people who experience mental stress, such as care workers.

Various common chemicals may harm the immune system, causing it to malfunction. This is known as immunotoxicity. These harmful effects may be temporary or permanent.

Possible immunotoxic effects include:

  • hypersensitivity
  • chronic inflammation
  • immunosuppression, or an impairment of the body’s ability to fight off infections
  • immunostimulation, which can cause tissue damage through immune responses
  • autoimmunity

In particular, if an immunotoxic substance causes the body to produce fewer antibodies, it can have an effect on the fight against active infections and the protection against future ones.

The FDA currently require immunotoxicity testing for food additives. However, most food additives received approval decades ago, and the FDA do not mandate updated testing on previously approved additives.

TBHQ and PFAS

TBHQ is a common preservative that manufacturers use to prolong their products’ shelf lives.

According to the Environmental Working Group (EWG), it is present in almost 1,250 processed foods, including Cheez-It crackers, Pop-Tarts, Reese’s Peanut Butter Cups, and Little Debbie Swiss Rolls.

However, this chemical has had immunotoxic effects in animal studies.

Chemicals may also leach from packaging or food processing equipment into food. Some bags, boxes, and food wrappers are coated with per- and polyfluoroalkyl substances (PFAS).

PFAS-based materials are also common in non-stick coatings on cookware, gaskets in food processing equipment, and repeat-use plastics.

The FDATrusted Source require immunotoxicity testing only for food contact substances with a high daily exposure. The immunotoxicity of many food additives and food contact substances is largely unknown.

The Environmental Protection Agency (EPA) use high throughput in-vitro testing in their ToxCast program. This type of testing exposes living cells, proteins, or biological molecules in a laboratory environment to chemicals to assess and identify any potential toxic effects. This potentially limits the need for animal testing.

The sparsity of current immunotoxicity data prompted the researchers from the EWG to conduct a study to evaluate the immunotoxic effects of common food additives and food contact substances. They also assessed the utility of ToxCast data in screening for immunotoxicity.

Lead study author Dr. Olga Naidenko, Ph.D., EWG’s vice president for science investigations, emphasizes the urgency of this research:

“The pandemic has focused public and scientific attention on environmental factors that can impact the immune system. Before the pandemic, chemicals that may harm the immune system’s defense against infection or cancer did not receive sufficient attention from public health agencies. To protect public health, this must change.”

The researchers analyzed a total of 63 direct food additives present on more than 10 product labels sold in the U.S. in 2018–2020. They also specifically assessed nine identified PFAS that migrate from food packaging to food.

The findings now appear in the International Journal of Environmental Research and Public Health.

The study evaluated these substances, concentrating on those with the highest number of active ToxCast assays. It focused further analyses on those substances with activity toward multiple immune-related targets and proteins involved in immune response, inflammation, and defense mechanisms.

The study compared the results of high throughput ToxCast data with available data from animal and epidemiological studies.

Altered immune responses

Strong data from both ToxCast testing and immunological laboratory animal studies indicate that TBHQ may cause immune functioning changes.

However, ToxCast screening yielded data that did not always agree with existing data: There were cases wherein ToxCast data conflicted with previous data or indicated risks that previous data had not found.

Three different situations happened with the food colorant FD&C Red 3 and PFAS such as perfluoroundecanoic acid (PFUnDA) and perfluorooctanoic acid (PFOA).

In the study, the ToxCast data indicated that FD&C Red 3 affected multiple immune parameters, but the researchers did not find reference to any animal or epidemiological study into the immunotoxicity of this food colorant.

ToxCast, laboratory animal, and human study data demonstrated that PFUnDA affected multiple immune parameters and increased immune suppression risk.

However, the ToxCast data did not show strong activity for immune targets with PFOA, whereas animal and human studies demonstrated immunosuppressive effects.

The study attributed the lack of consistency in the findings to a lack of understanding of the exact mechanism of PFAS toxicity. The limitations of currently available high throughput testing to capture the full extent of the potential mechanism for immunotoxicity may also have had an impact.

The researchers conclude that both ToxCast and study data suggest that chemicals indirectly or directly added to foods, such as THBQ and PFAS, may adversely affect immune system functioning.

The EWG stress that the FDA should prioritize and integrate updated immunotoxicity testing to identify harmful chemicals into standard safety assessments to protect public health and well-being.

Scott Faber, senior vice president for government affairs at the EWG, adds, “Food manufacturers have no incentive to change their formulas. Too often, the FDA [allow] the food and chemical industry to determine which ingredients are safe for consumption.”

“Our research shows how important it is that the FDA take a second look at these ingredients and test all food chemicals for safety.”

Many people have chronic stress and anxiety. They face symptoms such as nervousness, agitation, tension, a racing heart, and chest pain.

In fact, anxiety is among the most common mental health issues. In the United States, more than 18 percent of adults are affected by anxiety disorders each year.

In some cases, another health condition, such as an overactive thyroid, can lead to an anxiety disorder. Getting an accurate diagnosis can ensure that a person receives the best treatment.

In this article, learn about a wide range of natural and home remedies that can help with stress and anxiety.

Natural remedies for anxiety and stress

Natural remedies are generally safe to use alongside more conventional medical therapies.

However, alterations to the diet and some natural supplements can change the way antianxiety medications work, so it is essential to consult a doctor before trying these solutions. The doctor may also be able to recommend other natural remedies.

1. Exercise

woman-jogging-through-park-listening-to-headphones
Exercise may help to treat anxiety.

Exercise is a great way to burn off anxious energy, and research tends to support this use.

For example, a 2015 review of 12 randomized controlled trials found that exercise may be a treatment for anxiety. However, the review cautioned that only research of higher quality could determine how effective it is.

Exercise may also help with anxiety caused by stressful circumstances. Results of a 2016 studyTrusted Source, for example, suggest that exercise can benefit people with anxiety related to quitting smoking.

2. Meditation

Meditation can help to slow racing thoughts, making it easier to manage stress and anxiety. A wide range of meditation styles, including mindfulness and meditation during yoga, may help.

Mindfulness-based meditation is increasingly popular in therapy. A 2010 meta-analytic review suggests that it can be highly effective for people with disorders relating to mood and anxiety.

3. Relaxation exercises

Some people unconsciously tense the muscles and clench the jaw in response to anxiety. Progressive relaxation exercises can help.

Try lying in a comfortable position and slowly constricting and relaxing each muscle group, beginning with the toes and working up to the shoulders and jaw.

4. Writing

Finding a way to express anxiety can make it feel more manageable.

Some research suggests that journaling and other forms of writing can help people to cope better with anxiety.

2016 study, for example, found that creative writing may help children and teens to manage anxiety.

5. Time management strategies

Some people feel anxious if they have too many commitments at once. These may involve family, work, and health-related activities. Having a plan in place for the next necessary action can help to keep this anxiety at bay.

Effective time management strategies can help people to focus on one task at a time. Book-based planners and online calendars can help, as can resisting the urge to multitask.

Some people find that breaking major projects down into manageable steps can help them to accomplish those tasks with less stress.

6. Aromatherapy

Smelling soothing plant oils can help to ease stress and anxiety. Certain scents work better for some people than others, so consider experimenting with various options.

Lavender may be especially helpful. A 2012 study tested the effects of aromatherapy with lavender on insomnia in 67 women aged 45–55. Results suggest that the aromatherapy may reduce the heart rate in the short term and help to ease sleep issues in the long term.

7. Cannabidiol oil

cbd-oil
CBD oil comes from the marijuana plant.

Cannabidiol (CBD) oil is a derivative of the cannabis, or marijuana, plant.

Unlike other forms of marijuana, CBD oil does not contain tetrahydrocannabinol, or THC, which is the substance that creates a “high.”

CBD oil is readily available without a prescription in many alternative healthcare shops. Preliminary research suggests that it has significant potential to reduce anxiety and panic.

In areas where medical marijuana is legal, doctors may also be able to prescribe the oil.

8. Herbal teas

Many herbal teas promise to help with anxiety and ease sleep.

Some people find the process of making and drinking tea soothing, but some teas may have a more direct effect on the brain that results in reduced anxiety.

Results of a small 2018 trial suggest that chamomile can alter levels of cortisol, a stress hormone.

9. Herbal supplements

Like herbal teas, many herbal supplements claim to reduce anxiety. However, little scientific evidence supports these claims.

It is vital to work with a doctor who is knowledgeable about herbal supplements and their potential interactions with other drugs.

10. Time with animals

Pets offer companionship, love, and support. Research published in 2018 confirmed that pets can be beneficial to people with a variety of mental health issues, including anxiety.

While many people prefer cats, dogs, and other small mammals, people with allergies will be pleased to learn that the pet does have to be furry to provide support.

2015 studyTrusted Source found that caring for crickets could improve psychological health in older people.

Spending time with animals can also reduce anxiety and stress associated with trauma. Results of a 2015 systematic reviewTrusted Source suggest that grooming and spending time with horses can alleviate some of these effects.

Other treatment options

person-having-counseling-or-therapy
Therapy may help to treat chronic anxiety.

Anxiety that is chronic or interferes with a person’s ability to function warrants treatment.

When there is no underlying medical condition, such as a thyroid problem, therapy is the most popular form of treatment.

Therapy can help a person to understand what triggers their anxiety. It can also help with making positive lifestyle changes and working through trauma.

One of the most effective therapies for anxiety is called cognitive behavioral therapy (CBT). The goal is to help a person understand how their thoughts affect their emotions and behavior and to replace those reactions with positive or constructive alternatives.

CBT can help with generalized anxiety and anxiety relating to a specific issue, such as work or an instance of trauma.

Medication can also help a person to manage chronic anxiety. A doctor may prescribe medications in any of the following groups:

  • antianxiety drugs called benzodiazepines, including Xanax and Valium
  • antidepressants called selective serotonin reuptake inhibitors, including Prozac
  • sleeping medications, if anxiety interferes with sleep

People should follow the doctor’s instructions when using these drugs, as they can have severe and possibly life threatening adverse effects.

Natural anxiety remedies can replace or complement traditional treatments.

Outlook

Untreated anxiety can get worse and cause more stress in a person’s life. However, anxiety is highly treatable with therapy, natural remedies, lifestyle changes, and medications.

A person may need to try several combinations of therapies and remedies before finding one that works. A doctor can help a person to determine which options are best.