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Salt

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Researchers suggest that sodium – which we commonly ingest through salt, or sodium chloride – could increase the risk of type 2 diabetes and latent autoimmune diabetes in adults.

Diabetes is a common condition that affects more than 29 million people in the United States, according to the Centers for Disease Control and Prevention (CDC). Type 2 diabetes accounts for up to 95 percent of all diagnosed cases and is characterized by abnormal levels of blood sugar.

This type of diabetes is most often diagnosed in middle-aged and senior people. Another metabolic condition called latent autoimmune diabetes in adults (LADA) is often misdiagnosed as type 2 diabetes; it also appears later in adulthood.

LADA is a more slowly progressing disease, and it does not initially require insulin treatment.

A new study conducted by Dr Bahareh Rasouli, of the Institute of Environmental Medicine at the Karolinska Institutet in Stockholm, Sweden – in collaboration with researchers from other Swedish and Finnish institutions – now looks at the impact of sodium intake on the risk of type 2 diabetes and LADA.

The researchers have presented their findings at the annual meeting of the European Association for the Study of Diabetes, held in Lisbon, Portugal.

High sodium intake may be a risk factor

Existing research had already suggested that the sodium we usually absorb from our daily intake of salt may significantly increase the risk of developing type 2 diabetes.

The team explains that this may be because sodium impacts insulin resistance, but also because excess salt can lead to hypertension and gaining excess weight. But until now, no studies had looked at the impact of sodium intake on the risk of LADA.

Dr Rasouli and colleagues analyzed data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes, which is a large Swedish cohort study.

Questionnaires were used to collect information about the participants’ daily diets. These data then allowed the team to calculate the daily caloric, nutrient, and sodium intake for each participant.

Dr Rasouli and colleagues also took into consideration genetic risk factors for diabetes, and the participants were split into “high risk” and “other” categories depending on their genetic profile.

Confounding variables, including age, sex, body mass index (BMI), smoking, physical activity levels, and alcohol intake, were also adjusted for.

The researchers found that each extra gram of sodium (or 2.5 grams of salt) per day was linked to a 43 percent higher risk of type 2 diabetes. For LADA, each extra gram of sodium led to a 73 percent increase in developing the condition.

Participants were also divided into three groups depending on the quantity of their sodium intake. These were “low consumption” (for under 2.4 grams of sodium daily, or up to 6 grams of salt), “medium consumption” (2.4 to 3.15 grams of sodium, or up to 7.9 grams of salt), and “high consumption” (more than 3.15 grams of sodium daily, or more than 7.9 grams of salt).

It was noted that the people who fell within the high consumption category were at a 58 percent higher risk of developing type 2 diabetes than the individuals in the low consumption group.

People with a high genetic risk of diabetes who also had a high daily sodium intake were almost four times as likely to develop LADA than people with a low daily intake of sodium.

Based on these findings, the researchers “confirm an association between sodium intake and type 2 diabetes.” They add that “high sodium intake may be a risk factor for LADA, especially in carriers of high risk HLA [human leukocyte antigen] genotypes.” These are people who already carry a significant genetic risk of diabetes.

The authors suggest that their study may lead to fresh prevention strategies for diabetes, and especially LADA.

These findings may have important implications in the primary prevention of diabetes with adult onset.

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Having neither too high nor too low levels of sodium [salt] is optimal for health

HealthDay news image– A controversial new study contends that a low-salt diet could be dangerous for your heart health.

Restricting dietary salt to below 3,000 milligrams a day appears to increase the risk for heart disease similar to that of high blood pressure patients who eat too much salt, said lead researcher Andrew Mente.

“Having neither too high nor too low levels of sodium [salt] is optimal for health,” said Mente, an associate professor of clinical epidemiology and biostatistics at McMaster University, in Ontario, Canada.

The American Heart Association is highly critical of Mente’s study. The AHA says the study relies on incorrect estimates of sodium intake, and should not lead anyone to relax concerns over excess salt in the average U.S. diet.

“This is an extremely flawed analysis that doesn’t provide new information, and it should not be used to guide public policy,” said Dr. Elliott Antman, immediate past president of the AHA and an associate dean for clinical and translational research at Harvard Medical School.

“The American Heart Association continues to recommend less than 1,500 milligrams of sodium per day from all sources,” he said.

Most Americans consume about 3,400 milligrams of sodium a day, more than twice the recommended amount, according to the heart association.

Mente said, based on his analysis, only people with high blood pressure need to worry about reducing salt intake.

He said his study results showed that a low-salt diet increases the risk of heart attack or stroke 26 percent for people without high blood pressure and 34 percent for people with high blood pressure.

For those with high blood pressure, too much dietary salt increases their risk 23 percent, the study said.

On the other hand, a diet with excess salt doesn’t increase the risk at all if blood pressure is normal, the study reported.

“Most of the population eats what they’re supposed to eat, based on the data,” Mente said. “They fall in the middle and that’s actually the sweet spot — the safest range of intake.”

Excess salt increases blood pressure in some people by causing the body to retain water, putting extra strain on the heart, the heart association says.

Mente said a low-salt diet can activate the body’s renin-angiotensin system. This is a hormone process that regulates blood pressure and fluid balance.

“If you attempt to reduce your blood pressure by lowering your sodium, you’re lowering your blood pressure but you’re activating your renin-angiontensin system,” Mente said.

For their analysis, Mente and his colleagues pooled results of four studies that measured salt intake and tracked heart health. Together, the studies involved more than 133,000 people from 49 countries.

Each study used a single, morning urine sample from each person to estimate their regular daily salt intake for extended periods of time, an approach the AHA’s Antman called “deficient.”

People with less than 3,000 milligrams of sodium in their urine were assigned to the low-sodium group, while 7,000 or more milligrams of urinary sodium was considered high-sodium.

Antman said, “They (the study authors) make the assumption that a measurement of urine sodium in a spot fashion like this, at one moment in time, can reliably inform us about what the sodium intake was during the course of the study.”

Antman is concerned that news reports of this study will lead people to make diet choices that could prove disastrous to their heart health.

“Unless we point out the deficiencies with this analysis, there could be a major public health problem,” he said.

The study results were published May 20 in The Lancet.

Sharon Zarabi, a registered dietitian at Lenox Hill Hospital in New York City, said salt has been a part of the human diet for millennia. But, the advent of processed foods has led to its use in larger doses for flavor and as a preservative, she said.

“We treat patients with hypertension [high blood pressure] with the DASH dietary approach, a diet which includes a variety of fruits and vegetables and limits added salt,” Zarabi said. “As most dietary research studies claim ‘everything in moderation,’ try to avoid condiments and processed foods that have more salt than you might expect, such as salad dressings, mustard, cheese, sauces and even bread products.”

Dr. Howard Levite, director of cardiology for Staten Island University Hospital in New York City, said the idea that most people are consuming the right amount of salt is “controversial.” This new analysis does not disprove the need to watch salt intake as a means of warding off heart disease, he added.

“The article raises the possibility that once achieving middle age the current sodium guidelines for an individual may need to be liberalized. But, this in no way detracts from the prevention goals that are the raison d’etre of the established protocols,” Levite said.

SOURCES: Andrew Mente, Ph.D., associate professor, clinical epidemiology and biostatistics, McMaster University, Ontario, Canada; Elliott Antman, M.D., immediate past president, American Heart Association, and associate dean, clinical and translational research, Harvard Medical School, Boston; Sharon Zarabi, R.D., Lenox Hill Hospital, New York City; Howard Levite, M.D., director, cardiology, Staten Island University Hospital; May 20, 2016, The Lancet

Source: HealthDay