Ebola

by -
0 843

Ebola Nigeria should not be complacent with its Ebola free status. This is the consensus coming out of the first day of a 3-day meeting of a group of Nigerian doctors in the Americas.

Participants which include former Nigerian Minister of Health, Professor Onyebuchi Chukwu, Commissioners of Health and medical officials from the First Consultant Hospital, Lagos Island, outlined strategies that can prepare the country for future epidemics.

The current state of the Ebola outbreak in a few West African countries and lessons learnt from the importation of the disease into Nigeria shaped the opening conversations of the 3-day conference which has other physicians from Nigeria in attendance.

Nigeria, sadly with casualties but thankfully also survivors, contained the 2014 Ebola infection to earn her current W.H.O Ebola free status.

The experts have, however, warned that a reappearance of the disease in Liberia, which was equally certified free of the virus, should send a strong signal of a possible re-importation.

The Association of Nigerian Physicians in the Americas (ANPA) has been doing this for 21 years, bringing onto the discussion table, burning issues in Africa and particularly in the Nigerian health sector.

Discussions on healthcare delivery during conflicts, disasters and epidemics continue on Friday with a focus on managing victims of terrorist attacks.

The 2015 Conference of the Association of Nigerian Physicians in the Americas is being held in Orlando, Florida in the United States.

by -
0 630

The World Health Organisation (WHO) has warned that recovery from Ebola will be impossible unless resilient health systems are rebuilt in Guinea, Liberia and Sierra Leone.

The world health body in a message yesterday on its website said recovery in West Africa needs more urgency as the region’s battered systems have limited capacity to reactivate essential health services.

In the lead-up to a major fundraising conference for Ebola recovery, the WHO described rebuilding of the national health systems in West Africa as a critical priority.

“While the countries are still working to get to zero Ebola cases, staying at zero is inconceivable unless rebuilding of the health systems begins now.”

According to Dr Matshidiso Moeti, WHO regional director for Africa, “Guinea, Liberia and Sierra Leone entered the Ebola epidemic with severely underfunded health systems. After a year of handling far too many severely ill patients, the surviving staff need support, better protection, compensation and reinforcements. The existing facilities need a complete overhaul, and many new structures need to be built. If another outbreak strikes, the toll would be far worse.”

“Outbreaks of contagious diseases can flare up anywhere,” said Marie-Paule Kieny, WHO assistant director-general for Health Systems and Innovation. “But the size of the Ebola outbreak in West Africa is directly related to the lack of resilience of the national health systems. In West Africa, the governments did not have the tools or resources to identify the initial cases or control the outbreak that resulted.”

“National pride will not stop a viral outbreak on its own,” said Dr. Philip Ireland, an emergency medicine physician at John F. Kennedy Hospital in Monrovia, Liberia. “But it provides a strong foundation for building a new health system; the one we had collapsed under the weight of Ebola. The hiring of well-trained doctors and technicians, nurses and physician assistants should be our nation’s number one priority.”

According to a WHO report released in May, Ebola took an exceptional toll on health workers. They were 20-30 times more likely to contract the disease than the general public, given the number of patients they saw and treated. More than 800 contracted Ebola, and more than 400 died – with the outcome of almost one quarter of the cases unknown.

The health systems of all three countries need an exceptional infusion of funding and other resources, the focus of the United Nations Secretary-General’s International Ebola Recovery Conference (9-10 July, 2015).

“To rebuild their health systems and provide services from now through the end of December, 2017, Guinea has budgeted $1.176 billion and still needs to raise $386.5 million; Liberia has budgeted $550 million and still needs to raise $169.7 million; and Sierra Leone budgeted $361 million and still needs to raise an estimated amount of $140 million,” the WHO said in the statement.

A sizable investment in the health systems would be a profound change of course for the region. As with other low-income countries, the governments of all three countries have not spent enough money on health care to provide basic services, and the life expectancy of the populations has suffered greatly as a result.

Dr Kieny added, “In this interconnected world of international travel and porous borders, no one is immune from disease outbreaks. This is the lesson the West African Ebola outbreak has taught us. We need to ensure that health systems everywhere can detect and treat emerging diseases and still keep their routine healthcare services up and running.”

“When people think global health security, they think disease surveillance,” said Dr. Moeti. “Nobody wants to see the Ebola outbreak start in West Africa and spread around the world. But disease surveillance cannot happen in a vacuum. Emerging disea

by -
0 755

Just in case you do not know, three fresh cases of the Ebola Virus Disease have been confirmed in Liberia and Sierra Leone in the last two weeks.

It is obviously not good news to citizens who lost their loved ones on the one hand, and health officials who lost colleagues to the virus while the infections lasted in West Africa.

These new cases popped up when both countries were thought to have been rid of the infectious disease that killed over 10,000 persons globally.

Nigeria lost some of her brilliant professionals to EVD in 2014. Worthy of note is the late senior physician, Dr. Stella Adadevoh, who handled the treatment of the index case.

Some may wonder why there were so many causalities. The reason is simple: Ebola is a highly infectious disease, such that one can contact it just by touching the surface that an infected person had touched previously.

Ebola is regarded in the medical world as the deadliest virus on earth, not only because it has no known cure yet, but also because it is one of the world’s lethal infections: it could kill within hours or few days of symptom onset, whether an infected person gets treatment or not.

The initial symptoms of the viral disease can include sudden fever, intense weakness, muscle pain and sore throat; and it can later progress to vomiting, diarrhoea and, in some cases, internal and external bleeding.

Scientists note that the fearful aspect of the disease is that it is highly infectious. It has killed both doctors and patients alike. It does not respond to any vaccine. It can live in the body system of an infected person for two days to three weeks without any symptoms.

Worse still, Ebola is difficult to diagnose. Doctors note that by the time the symptoms start to manifest in an infected person, it is often too late to stop the spread of the virus to vital organs of the body. The best treatment affected persons get is therapy.

Experts say we must not forget the very important lessons and habits we learnt from the last Ebola outbreak.

Preventing infection

Reiterating the need for residents to adopt urgent precautionary measures against the disease, the Permanent Secretary in the State Ministry of Health, Dr. Modele Osunkiyesi, urges members of the public to observe and maintain high standards of personal and environmental hygiene to prevent another outbreak of the highly infectious disease.

Osunkiyesi notes that the main host of the virus is relatively unknown; however, she says, there is enough scientific evidence to show that Ebola virus can be contracted by persons handling sick or dead infected wild animals, including chimpanzees, gorillas, monkeys, forest antelope, and fruit bats.

She says, “Ebola virus can be spread through close contact with the blood, body fluids, organs and tissues of infected animals; direct contact with blood, organ or body secretions of an infected person. The transmission of the virus by other animals like monkey and chimpanzee cannot be ruled out.”

Osunkiyesi states that those at the highest risk of contracting the disease include health care workers who treat patients without taking necessary precautions against infection; and families or friends of an infected person who could be infected in the course of feeding, holding and caring for the sick.

She notes that one could contract the virus from an infected person as long as their blood and secretions contain the virus – in some cases, up to seven weeks after they have recovered. Even those who come in contact with body fluids of a person killed by this virus are not exempted!

Recognise the risk

She adds that though there is no specific treatment for the disease, persons with symptoms – including bleeding from the eyes, mouth, nose, rectum and ear; or those suffering from fever, malaria and cholera – should report to the health centres closest to them, where they would be admitted for special care and treated in isolation.

Hunters and those who eat or handle game meat of monkeys and chimpanzees are also at risk, experts say; that is why the World Health Organisation warns against consuming raw bush meat and forbids any contact with infected bats, monkeys and apes, saying that these game meats were considered delicacies in the areas where the outbreak started.

Wash your hands

Public health physician, Dr. Segun Adeboye, notes that the importance of washing one’s hands with soap and water to get rid of germs, bacteria and other viruses cannot be overemphasised.

According to him, this age-long habit has been proved to reduce the risk of getting infections by more than 60 per cent.

Adeboye says, “Many people are aware of washing of hands, but what we are saying is that you should use soap or disinfectant when you wash hands. That is what will kill the bacteria or virus.

“Also, the hand is the means by which most infections are contracted. And the average person touches his/her mouth at least 10 times a day. Imagine if you had touched an infected person with your hand unknowingly, and you don’t wash your hand before eating.

“You have introduced a virus into your body just by being negligent. Science has proved that 70 per cent of infections are contracted via the mouth through the hands.”

If you can’t access potable water, you can always improvise with hand sanitisers. They are portable, which means you can carry one in your bag, car and in your office locker.

PUNCH.

by -
0 1056

In its bid to support global efforts aimed at stamping out Ebola in West Africa, telecoms operator, Airtel Nigeria, has announced a new SMS short code, 7979, that will help raise funds and drive awareness for the initiative.

Chief Executive Officer/Managing Director of Airtel Nigeria, Mr. Segun Ogunsanya, said the telecoms firm had partnered with the African Union towards this end.

He said the initiative, operating under the hash tag #AfricaAgainstEbola, would use the 7979 dedicated platform to raise funds for the deployment of African health workers to affected countries.

He said in order to support the initiative, Airtel customers are encouraged to send ‘StopEbola’ as an SMS to 7979 at N100 per SMS.

“As a major stakeholder with operations in 17 African countries, we are intensely interested in the communities and people we serve, just as we are passionate about creating platforms to uplift the less privileged.

“This partnership with AU provides a fine opportunity for all of us at Airtel Nigeria to join in kicking Ebola out of Africa. We are committed to the partnership with the African Union on this initiative, as it is in sync with our corporate social responsibility strategy of touching and saving lives.

“All monies realised from the SMS campaign will be donated in full to the AU Fund that has been set up to kick Ebola out of Africa,” Ogunsanya said.

The CEO had earlier donated mobile phones, sim cards and airtime to all the 290 Nigerian doctors, nurses and other care-givers who have volunteered to join the fight against Ebola.

He urged other private organisations to emulate Airtel in the effort to raise funds and awareness for the fight against the disease that has claimed over 9,637 lives across West Africa.

by -
0 657

Marburg virus is Ebola’s deadly cousin. The virus is up to 90 percent lethal – and doctors are desperate for tools to fight it.

Now scientists at The Scripps Research Institute have captured the first images showing how immune molecules bind to a site on the surface of Marburg virus. The images are like enemy reconnaissance, showing scientists how to target the virus’s weak spots with future treatments.

The research team is also the first to describe an antibody that binds to both Marburg and Ebola viruses, paving the way for new antibody treatments to fight an entire family of viruses.

“These cross-reactive antibodies are a straightforward route to a therapeutic,” said TSRI Professor Erica Ollmann Saphire, senior author of new study. “You could use these antibodies directly against Marburg virus or – with a bit more engineering – use them to also target Ebola virus.”

Their findings were published February 26 in the journal Cell.

Marburg virus is spread to humans by bats and can cause massive haemorrhaging and organ failure, just like Ebola virus. In 2005, a Marburg outbreak in Angola killed 329 people, mostly children and health-care workers. Some worry Marburg could cause an even bigger outbreak in the future.

“Marburg is just as likely as Ebola to migrate to a densely populated area,” said Saphire.

Marburg has a weakness

The new study focuses on an antibody discovered in the blood of a Marburg survivor. By studying how the antibody binds to the virus, the researchers hoped to find new points of attack on Marburg’s surface.

The project was a six-year effort in the Saphire lab. Takao Hashiguchi, a former TSRI research associate, and Marnie Fusco, a TSRI research assistant, figured out how to grow crystals of the antibody attached to its viral target. This crystal was then exposed to X-ray diffraction at the Photon Factory synchrotron in Tsukuba, Japan, revealing its shape in three dimensions.

The team’s work showed how the antibody attaches to Marburg virus, blocking the virus’s ability to bind to a receptor and get its genetic material into human cells. This was also the first time that Marburg’s glycoprotein had been seen in the form it takes as it infects cells.

Could it fight Ebola too?

Marburg and Ebola viruses enter cells the same way, so the researchers wondered if the antibody could also inactivate Ebola virus by binding to the same site. The work of TSRI Staff Scientist Zachary Bornholdt showed that it did bind to Ebola – and provided a crystal structure of the same antibody bound to Ebola virus.

The crystal structure also revealed why this cross-reactive antibody was found in a Marburg survivor and not an Ebola survivor, even though the antibody reacts with both viruses. The key was in the flexible, carbohydrate-rich coating on the surface proteins of both viruses. With the help of researchers at the Lawrence Berkeley National Laboratory, the team used a technique called small-angle X-ray scattering to study the carbohydrate-cloaked versions of the Ebola and Marburg proteins.

Their images showed that the carbohydrate-rich regions had different shapes and exposed different surfaces underneath, allowing the body to create an antibody against this exposed region only in Marburg.

The new study was published in Cell with a companion paper, led by researcher James E. Crowe Jr. at Vanderbilt University and co-authored by TSRI Associate Professor Andrew Ward and C. Daniel Murin, a TSRI graduate student. This paper shows low-resolution structures of other antibodies with the potential to bind to the same vulnerable receptor on Marburg virus.

Ward said the two studies give him hope that a cross-reactive antibody treatment could someday be designed to combat related viruses, such as Sudan virus and Bundibugyo virus, which share the receptor. “We need to be prepared for future outbreaks,” said Ward.

“You don’t know which virus is going to break out next,” said Saphire. “This gives us something to work with.”

sciencedaily.com